Drug Information

Drug General Information
Drug ID
D03NPA
Former ID
DNC010342
Drug Name
Ganoderic acid A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530656]
Structure
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2D MOL

3D MOL
Formula
C30H44O7
Canonical SMILES
CC(CC(=O)CC(C)C(=O)O)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(<br />=O)C4(C)C)C)O)C)C)O
InChI
1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1
InChIKey
DYOKDAQBNHPJFD-JNTBEZBXSA-N
PubChem Compound ID
471002
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 2 Target Info Inhibitor [530656]
KEGG Pathway Steroid hormone biosynthesis
Aldosterone-regulated sodium reabsorption
NetPath Pathway EGFR1 Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 530656Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. Epub 2010 Jan 11.11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.
Ref 530656Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. Epub 2010 Jan 11.11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.

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