Drug General Information
Drug ID
D03OTH
Former ID
DNCL002096
Drug Name
Belagenpumatucel-L
Synonyms
Lucanix (TN)
Drug Type
Vaccine
Indication Non-small cell lung cancer; Small-cell lung cancer [ICD9: 162.9; ICD10:C33-C34] Phase 3 [522320]
Company
NovaRx
Target and Pathway
Target(s) mRNA of TGF beta-2 ligand Target Info [550419]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ATF-2 transcription factor network
Signaling events mediated by the Hedgehog family
Regulation of retinoblastoma protein
TGF-beta receptor signaling
Reactome Platelet degranulation
Molecules associated with elastic fibres
ECM proteoglycans
WikiPathways Endochondral Ossification
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
NRF2 pathway
Extracellular vesicle-mediated signaling in recipient cells
Extracellular matrix organization
Elastic fibre formation
References
Ref 522320ClinicalTrials.gov (NCT00676507) Phase III Lucanix Vaccine Therapy in Advanced Non-small Cell Lung Cancer (NSCLC) Following Front-line Chemotherapy. U.S. National Institutes of Health.
Ref 550419National Cancer Institute Drug Dictionary (drug id 590662).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.