Drug Information
Drug General Information | |||||
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Drug ID |
D03PIO
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Former ID |
DNC010245
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Drug Name |
IODORESINIFERATOXIN
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529209] | ||
Structure |
Download2D MOL |
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Formula |
C37H39IO9
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Canonical SMILES |
CC1CC2(C3C4C1(C5C=C(C(=O)C5(CC(=C4)COC(=O)CC6=CC(=C(C(=<br />C6)I)O)OC)O)C)OC(O3)(O2)CC7=CC=CC=C7)C(=C)C
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InChI |
1S/C37H39IO9/c1-20(2)35-16-22(4)37-26(33(35)45-36(46-35,47-37)18-23-9-7-6-8-10-23)12-25(17-34(42)29(37)11-21(3)32(34)41)19-44-30(39)15-24-13-27(38)31(40)28(14-24)43-5/h6-14,22,26,29,33,40,42H,1,15-19H2,2-5H3/t22-,26+,29-,33-,34-,35-,36-,37-/m1/s1
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InChIKey |
TZUJORCXGLGWDV-DZBJMWFRSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Transient receptor potential cation channel subfamily V member 4 | Target Info | Inhibitor | [527001] | |
Vanilloid receptor 1 | Target Info | Inhibitor | [529209] | ||
Vanilloid receptor | Target Info | Inhibitor | [529209] | ||
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
References | |||||
Ref 527001 | Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. | ||||
Ref 529209 | J Med Chem. 2008 Jan 10;51(1):57-67. Epub 2007 Dec 12.Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. |
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