Drug Information

Drug General Information
Drug ID
D03PLH
Former ID
DIB021101
Drug Name
U46619
Synonyms
U 46619; U46619; 11alpha,9alpha-epoxymethano-PGH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539187]
Structure
Download
2D MOL
Formula
C21H34O4
InChI
InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1
InChIKey
LQANGKSBLPMBTJ-BRSNVKEHSA-N
PubChem Compound ID
5311493
PubChem Substance ID
7980859, 11532954, 12013056, 26754819, 26754820, 47588764, 48184758, 50110789, 57359501, 75369383, 85788966, 92309950, 99300863, 99302382, 103618489, 104046445, 104133960, 124800996, 135003867, 135651212, 135651289, 179205573, 188919927, 237362080, 241375699, 252156196, 252365326, 252455674
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534595]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525673]
Prostacyclin receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [534595]
Putative G-protein coupled receptor 44 Target Info Agonist [526477]
Prostaglandin F2-alpha receptor Target Info Agonist [525673]
Prostaglandin D2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534595]
Thromboxane A2 receptor Target Info Agonist [525673]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Platelet activation
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signalingtxa2pathway:Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and ProstacyclinPW000451:Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Endothelin Pathways
Platelet homeostasis
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
Vitamin D Receptor Pathway
Signal amplification
References
Ref 539187(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1888).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 526477Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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