TTD | Drug: D03PVF

Drug General Information
Drug ID	D03PVF
Former ID	DNC008514
Drug Name	2-(4-tosylpiperazin-1-yl)nicotinonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529500]
Structure		Download 2D MOL 3D MOL
Formula	C17H18N4O2S
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=C(C=CC=N3)C#N
InChI	1S/C17H18N4O2S/c1-14-4-6-16(7-5-14)24(22,23)21-11-9-20(10-12-21)17-15(13-18)3-2-8-19-17/h2-8H,9-12H2,1H3
InChIKey	NYLACAAEFWBUQQ-UHFFFAOYSA-N
PubChem Compound ID	16267445
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[529500]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 529500	Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. Epub 2008 May 10.Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Ref 529500	Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. Epub 2008 May 10.Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

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Drug Information