TTD | Drug: D03PYD

Drug General Information
Drug ID	D03PYD
Former ID	DNCL001740
Drug Name	K-604
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Phase 2	[522595]
Company	Kowa Pharmaceuticals America
Structure		Download 2D MOL 3D MOL
Formula	C27H26N2O2
Canonical SMILES	CC1CC(C2=CC=CC=C2N1C(=O)C3=CC=CC=C3)N(C4=CC=CC=C4)C(=O)<br />C5CC5
InChI	1S/C27H26N2O2/c1-19-18-25(29(27(31)21-16-17-21)22-12-6-3-7-13-22)23-14-8-9-15-24(23)28(19)26(30)20-10-4-2-5-11-20/h2-15,19,21,25H,16-18H2,1H3
InChIKey	VGFZCFWVSYIXEK-UHFFFAOYSA-N
PubChem Compound ID	57340709
PubChem Substance ID	136352740
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528287]
KEGG Pathway	Drug metabolism - other enzymes
KEGG Pathway	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 522595	ClinicalTrials.gov (NCT00851500) A Trial of the Safety and Efficacy of K-604 for the Treatment of Atherosclerosis. U.S. National Institutes of Health.
Ref 528287	A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7. Epub 2006 Jul 3.

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Drug Information