Drug Information

Drug General Information
Drug ID
D03QGB
Former ID
DNC002348
Drug Name
JNJ-5207852
Drug Type
Small molecular drug
Indication Narcolepsy [ICD9: 347; ICD10:G47.4] Investigative [538771]
Company
Johnson & Johnson
Structure
Download
2D MOL

3D MOL
Formula
C20H32N2O
InChI
InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2
InChIKey
PTKHFRNHJULJKT-UHFFFAOYSA-N
PubChem Compound ID
2766326
PubChem Substance ID
3196602, 5392837, 8302527, 14821295, 25782704, 39181268, 49665761, 78415116, 85227379, 88728348, 103361523, 103856695, 104045710, 109623889, 111376115, 125163397, 125444230, 135649651, 137128903, 139563581, 162507776, 172113486, 172919121, 179524509, 187581008, 198982782, 224053991, 229581697, 247251069
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [536039]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538771(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1256).
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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