Drug Information

Drug General Information
Drug ID
D03QKW
Former ID
DIB003626
Drug Name
KUC-7483
Synonyms
Ritobegron ethyl ester; KUC-7322; Beta 3 adrenoceptor agonists (urinary incontinence), Kissei; N-phenylglycine derivatives, Kissei; 4-hydroxynorephedrine derivative (urinary incontinence), Kissei
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Phase 1 [524942]
Company
Kissei Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c(cc(c(c1)C)CCN[C@H]([C@@H](c1ccc(cc1)O)O)C)C)OCC(=O<br />)OCC
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [531824], [531877]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 524942ClinicalTrials.gov (NCT02256735) Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin in Healthy Male and Female Volunteers. U.S.National Institutes of Health.
Ref 531824Mirabegron for the treatment of overactive bladder. Drugs Today (Barc). 2012 Jan;48(1):25-32.
Ref 531877Effects of ritobegron (KUC-7483), a novel selective beta3-adrenoceptor agonist, on bladder function in cynomolgus monkey. J Pharmacol Exp Ther. 2012 Jul;342(1):163-8.

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