Drug General Information
Drug ID	D03RTC
Former ID	DIB014140
Drug Name	BMS-812204
Synonyms	CB1 antagonists (obesity), BMS; CB1 antagonists (obesity), Bristol-Myers Squibb
Indication	Obesity [ICD9: 278; ICD10:E66]		Investigative	[543877]
Company	Bristol-Myers Squibb Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	FC(F)(c1nc(c(Cn2c(=O)c(c3cnc(nc3)C)c(c3n2c(=O)n(n3)CC)c<br />2ccc(cc2)Cl)cc1)C)F
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Antagonist	[543877]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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