Drug General Information
Drug ID	D03SAM
Former ID	DNC000012
Drug Name	(R)-alpha-methylhistamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538749]
Structure		Download 2D MOL 3D MOL
Formula	C6H11N3
InChI	InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
InChIKey	XNQIOISZPFVUFG-RXMQYKEDSA-N
PubChem Compound ID	156615
PubChem Substance ID	7978667, 11113570, 15146561, 16093057, 26751775, 46232384, 47434820, 47515539, 47885613, 48105152, 48179687, 48334726, 48404445, 49846718, 50065157, 50075028, 50104462, 57348301, 76714569, 90340819, 103173299, 103942877, 113435493, 117393350, 124749862, 129714812, 132626135, 134338589, 134346127, 135112540, 135650415, 135651165, 139603316, 140261834, 163425851, 164229681, 179151084, 184607645, 224300217, 226453626, 230109526, 244113949
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Agonist	[535262], [536039]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538749	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1236).
Ref 535262	Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist. Curr Med Chem. 2001 Sep;8(11):1329-40.
Ref 536039	The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.