| Drug General Information |
| Drug ID |
D03SGF
|
| Former ID |
DIB009377
|
| Drug Name |
WBZ-7
|
| Synonyms |
Imatinib analog (cancer), MD Anderson Cancer Center/Rice University
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
|---|
| Company |
MD Anderson Cancer Center
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
c1(c2cccnc2)nc(Nc2cc(NC(=O)c3ccc(cc3)CN3CCN(CC3)C)ccc2C<br />)nc(c1)C
|
| Target and Pathway |
| Target(s) |
Mast/stem cell growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Hematopoietic cell lineage
|
|
Melanogenesis
|
|
Pathways in cancer
|
|
Acute myeloid leukemia
|
|
Central carbon metabolism in cancer
|
|
NetPath Pathway
|
IL3 Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
KitReceptor Signaling Pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
Reactome
|
PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
RAF/MAP kinase cascade
|
|
WikiPathways
|
Kit receptor signaling pathway
|
|
Differentiation Pathway
|
|
Signaling by SCF-KIT
|
|
PIP3 activates AKT signaling
|
|
Cardiac Progenitor Differentiation
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805). |
|---|
