| Drug General Information |
| Drug ID |
D03TMD
|
| Former ID |
DNC003503
|
| Drug Name |
Barbituric acid derivative
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H11F3N2O3S
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Neuronal acetylcholine receptor protein, alpha-7 chain |
Target Info |
Antagonist |
[1]
|
|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric-acid receptor alpha-5 subunit |
Target Info |
Inhibitor |
[1]
|
| Gamma-aminobutyric-acid receptor alpha-3 subunit |
Target Info |
Inhibitor |
[1]
|
| Neuronal acetylcholine receptor protein, alpha-4 chain |
Target Info |
Antagonist |
[1]
|
| Gamma-aminobutyric-acid receptor alpha-2 subunit |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Nicotine addiction
|
|
Chemical carcinogenesishsa04080:Neuroactive ligand-receptor interaction
|
|
Retrograde endocannabinoid signaling
|
|
GABAergic synapse
|
|
Morphine addiction
|
|
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Nicotinic acetylcholine receptor signaling pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
|
|
Nicotine pharmacodynamics pathway
|
|
Reactome
|
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-975298:Ligand-gated ion channel transport
|
|
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
|
|
GABA A receptor activationR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
|
|
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
|
|
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-975298:Ligand-gated ion channel transport
|
|
GABA A receptor activation
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transportWP706:SIDS Susceptibility Pathways
|
|
Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Iron uptake and transport
|
| References |
| REF 1 | Whiting PJ: The <span class="caps">GABAA</span> receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. |
|---|
