| Drug General Information |
| Drug ID |
D03TTT
|
| Former ID |
DIB009614
|
| Drug Name |
AR-00341677
|
| Synonyms |
AR-00341677; GDC-0879; Anticancer program, Array/Genentech; B-Raf kinase inhibitors (cancer); B-Raf kinase inhibitors (cancer), Array/Genentech
|
| Drug Type |
Small molecular drug
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
|---|
| Company |
Array BioPharma Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H18N4O2
|
| InChI |
InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+
|
| InChIKey |
DEZZLWQELQORIU-RELWKKBWSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16822009, 23806501, 80606160, 99436996, 103643222, 124757002, 125163807, 126583484, 126634889, 126671631, 126724039, 131480758, 134964406, 136340131, 136367302, 136367934, 136920329, 136946695, 136959527, 137358532, 144116005, 151995972, 152258837, 152344244, 160647688, 162011561, 162037438, 162202587, 172660259, 174531364, 177749154, 180386838, 186022247, 188900392, 201500244, 223388386, 223684964, 223736290, 228576032, 251963966, 251971267, 252158073, 252160166, 252215463
|
| Target and Pathway |
| Target(s) |
B-Raf proto-oncogene serine/threonine-protein kinase |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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FoxO signaling pathway
|
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mTOR signaling pathway
|
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Vascular smooth muscle contraction
|
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Focal adhesion
|
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Natural killer cell mediated cytotoxicity
|
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Long-term potentiation
|
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Neurotrophin signaling pathway
|
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Serotonergic synapse
|
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Long-term depression
|
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Regulation of actin cytoskeleton
|
|
Insulin signaling pathway
|
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Progesterone-mediated oocyte maturation
|
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Alcoholism
|
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Hepatitis C
|
|
Pathways in cancer
|
|
Proteoglycans in cancer
|
|
Colorectal cancer
|
|
Renal cell carcinoma
|
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Pancreatic cancer
|
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Endometrial cancer
|
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Glioma
|
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Prostate cancer
|
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Thyroid cancer
|
|
Melanoma
|
|
Bladder cancer
|
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Chronic myeloid leukemia
|
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Acute myeloid leukemia
|
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Non-small cell lung cancer
|
|
NetPath Pathway
|
IL-7 Signaling Pathway
|
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PANTHER Pathway
|
Angiogenesis
|
|
Integrin signalling pathway
|
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Interleukin signaling pathway
|
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PDGF signaling pathway
|
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T cell activation
|
|
VEGF signaling pathway
|
|
Ras Pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
CDC42 signaling events
|
|
mTOR signaling pathway
|
|
Ras signaling in the CD4+ TCR pathway
|
|
ErbB1 downstream signaling
|
|
PDGFR-beta signaling pathway
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Trk receptor signaling mediated by the MAPK pathway
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
Spry regulation of FGF signaling
|
|
Frs2-mediated activation
|
|
ARMS-mediated activation
|
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CREB phosphorylation through the activation of Ras
|
|
RAF activation
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
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Negative regulation of MAPK pathway
|
|
WikiPathways
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
Estrogen signaling pathway
|
|
Senescence and Autophagy in Cancer
|
|
Regulation of Actin Cytoskeleton
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Cascade
|
|
MAPK Signaling Pathway
|
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Focal Adhesion
|
|
Bladder Cancer
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
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Polycystic Kidney Disease Pathway
|
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Corticotropin-releasing hormone
|
|
B Cell Receptor Signaling Pathway
|
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Signaling Pathways in Glioblastoma
|
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TSH signaling pathway
|
|
Integrated Breast Cancer Pathway
|
|
Signaling by FGFR
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Integrin-mediated Cell Adhesion
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5681). |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5681). |
|---|
