Drug Information

Drug General Information
Drug ID
D03TYI
Former ID
DAP000613
Drug Name
Aminophylline
Synonyms
Accurbron; Aerobin; Aerolate; Afonilm; Afonilum; Aminocardol; Aminodur; Aminofilina; Aminofillina; Aminophyllin; Ammophyllin; Aquaphyllin; Armophylline; Asmalix; Asmax; Austyn; Bilordyl; Bronchoparat; Bronkodyl; Bronkotabs; Cardiofilina; Cardiomin; Cardophylin; Cardophyllin; Carena; Cariomin; ConstantT; DOBO; Diaphilline; Diaphyllin; Diaphylline; Diffumal; Diophllin; Diophyllin; Diuxanthine; Doraphyllin; Duraphyl; Duraphyllin; Egifilin; Elixex; Elixicon; Elixomin; Elixophyllin; Etheophyl; Ethophylline; Eufilina;Euphyllin; Euphylline; Euphyllinum; Euphylong; Eurphyllin; Euufilin; Euufillin; Genophyllin; Grifomin; Hylate; Inophylline; LASMA; LaBID; Labophylline; Lanophyllin; Lasodex; Linampheta; Lixaminol; Maphylline; Medaphyllin; Metaphyllin; Metaphylline; Minaphil; Miofilin; Mudrane; Neophyiline; Norofilina; Nuelin; Optiphyllin; Parkophyllin; Peterphyllin; Phylcardin; Phyllindon; Phyllocontin; Phyllotemp; Physpan; Pulmidur; Quibron; Respbid; Respicur; Respid; SloPhyllin; Solosin; Somophyllin; SomophyllinT; Stenovasan; Sustaire; Synophylate; Syntophyllin; Talotren; Tefamin; Teofilina; Teofyllamin; Teolair; Teonova; Teosona; Tesona; Theacitin; Theobid; Theochron; Theocin; Theoclear; Theocontin; Theodel; Theodrip; Theodrox; Theodur; Theofol; Theograd; Theokin; Theolair; Theolamine; Theolix; Theolixir; Theolone; Theomin; Theonite; Theopek; Theophyl; Theophyldine; Theophyline; Theophyllin; Theophylline; Theoplus; Theospan; Theostat; Theotard; Theovent; Thephyldine; Truphylline; Unifyl; Unilong; Uniphyl; Uniphyllin; Uniphylline; Vasofilina; Xanthium; Xantivent; Aerolate III; Aerolate SR; Bronkodyl SR; Choledyl SA; Constant T; Nuelin SA; Quibron T; Quibron T SR; Quibron TSR; Slo Phyllin; THEOBID JR; Theo Dur; Theo von ct; Theoclear LA; Theodur G; Theona P; A 1755; BY 108; GS 2591A; Teocen 200; Theo 24; Theo24; Theoclear 80; Theostat 80; X 115; Acet-theocin; Constant-T; Ct, theo von; Minomal(TN); Nuelin S.A; Phyllocontin (TN); Pro-vent; Quibron T-SR; Quibron T/SR; Quibron-T; Slo-bid; Slo-phyllin; T-Phyl; TH/100; Telb-DS; Theo-11; Theo-24; Theo-DS; Theo-Nite; Theo-Sav; Theo-dur; Theobid Jr.; Theoclair-SR; Theoclear-80; Theolair-SR; Theophyl-225; Theophyl-SR; Truphylline (TN); Uni-Dur; Uniphyl (TN); Von ct, theo; Nuelin S.A.; Quibron-T/SR; Theo-24 (TN)
Drug Type
Small molecular drug
Indication Bronchial asthma [ICD9: 493; ICD10:J45] Approved [538346]
Asthma [ICD10:J45] Phase 2 [533467]
Therapeutic Class
Bronchodilator Agents
Structure
Download
2D MOL

3D MOL
Formula
C16H26N10O5
Canonical SMILES
CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2<br />.C(CN)N.O
InChI
1S/2C7H8N4O2.C2H8N2.H2O/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4;/h2*3H,1-2H3,(H,8,9);1-4H2;1H2
InChIKey
FCDVEQMNVIBKAU-UHFFFAOYSA-N
CAS Number
CAS 317-34-0
PubChem Compound ID
16218860
PubChem Substance ID
24277691, 28763726, 32021519, 47207100, 57381042, 118496676, 135348037, 143546335, 162250391, 198963702, 241225633, 252487606
SuperDrug ATC ID
R03DA05
SuperDrug CAS ID
cas=000314352
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [535425], [536386]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 533467Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.
Ref 538346FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 081142.
Ref 535425Spasmolytic effects of colforsin daropate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs. Acta Anaesthesiol Scand. 2002 Mar;46(3):297-302.
Ref 536386Topical fat reduction from the waist. Diabetes Obes Metab. 2007 May;9(3):300-3.

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