Drug General Information |
Drug ID |
D03UUO
|
Former ID |
DNC007454
|
Drug Name |
2-(2-(butylamino)pyrimidin-4-ylamino)benzoic acid
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Drug Type |
Small molecular drug
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Indication |
Discovery agent
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Investigative |
[1]
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Structure |
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Download
2D MOL
3D MOL
|
Formula |
C15H18N4O2
|
Canonical SMILES |
CCCCNC1=NC=CC(=N1)NC2=CC=CC=C2C(=O)O
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InChI |
1S/C15H18N4O2/c1-2-3-9-16-15-17-10-8-13(19-15)18-12-7-5-4-6-11(12)14(20)21/h4-8,10H,2-3,9H2,1H3,(H,20,21)(H2,16,17,18,19)
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InChIKey |
FSZJHCURVIQYSG-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Mitogen-activated protein kinase 8 |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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cAMP signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Protein processing in endoplasmic reticulum
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Wnt signaling pathway
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Osteoclast differentiation
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Focal adhesion
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Type II diabetes mellitus
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Non-alcoholic fatty liver disease (NAFLD)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Influenza A
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HTLV-I infection
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Pancreatic cancer
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Choline metabolism in cancer
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NetPath Pathway
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IL5 Signaling Pathway
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TNFalpha Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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B cell activation
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FAS signaling pathway
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Integrin signalling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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PDGF signaling pathway
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Parkinson disease
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TGF-beta signaling pathway
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T cell activation
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Toll receptor signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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RhoA signaling pathway
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Noncanonical Wnt signaling pathway
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CD40/CD40L signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Osteopontin-mediated events
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Reelin signaling pathway
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TRAIL signaling pathway
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CDC42 signaling events
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Signaling events regulated by Ret tyrosine kinase
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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IL1-mediated signaling events
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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FoxO family signaling
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Ceramide signaling pathway
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Regulation of Androgen receptor activity
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p75(NTR)-mediated signaling
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ErbB1 downstream signaling
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ATF-2 transcription factor network
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ErbB2/ErbB3 signaling events
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PDGFR-beta signaling pathway
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JNK signaling in the CD4+ TCR pathway
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Nephrin/Neph1 signaling in the kidney podocyte
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HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Retinoic acid receptors-mediated signaling
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Syndecan-2-mediated signaling events
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Ephrin B reverse signaling
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p53 pathway
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N-cadherin signaling events
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S1P2 pathway
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Downstream signaling in naï
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RAC1 signaling pathway
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Signaling events mediated by focal adhesion kinase
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Glypican 3 network
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IL12 signaling mediated by STAT4
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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NRAGE signals death through JNK
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NRIF signals cell death from the nucleus
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Oxidative Stress Induced Senescence
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FCERI mediated MAPK activation
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DSCAM interactions
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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
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Activation of the AP-1 family of transcription factors
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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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WikiPathways
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Toll-like receptor signaling pathway
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DNA Damage Response (only ATM dependent)
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TCR Signaling Pathway
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ErbB Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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MAPK Signaling Pathway
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TGF beta Signaling Pathway
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FAS pathway and Stress induction of HSP regulation
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Signaling of Hepatocyte Growth Factor Receptor
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Kit receptor signaling pathway
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Transcriptional activation by NRF2
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NLR Proteins
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IL-3 Signaling Pathway
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Cardiac Hypertrophic Response
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Nanoparticle-mediated activation of receptor signaling
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Structural Pathway of Interleukin 1 (IL-1)
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EBV LMP1 signaling
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JAK/STAT
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PDGF Pathway
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Nanoparticle triggered regulated necrosis
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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TNF alpha Signaling Pathway
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B Cell Receptor Signaling Pathway
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Prostate Cancer
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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Leptin signaling pathway
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RANKL/RANK Signaling Pathway
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Signalling by NGF
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IL-1 signaling pathway
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Intrinsic Pathway for Apoptosis
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DSCAM interactions
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Apoptosis Modulation and Signaling
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Type II diabetes mellitus
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MicroRNAs in cardiomyocyte hypertrophy
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Physiological and Pathological Hypertrophy of the Heart
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Regulation of toll-like receptor signaling pathway
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Osteoclast Signaling
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References |
REF 1 | Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2.Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. |