Drug Information

Drug General Information
Drug ID
D03VMX
Former ID
DIB019978
Drug Name
GW1100
Synonyms
GW1100; GW 1100; GW-1100
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538640]
Structure
Download
2D MOL
Formula
C27H25FN4O4S
InChI
InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3
InChIKey
PTPNCCWOTBBVJR-UHFFFAOYSA-N
PubChem Compound ID
11692123
PubChem Substance ID
16796456, 23786528, 42859041, 74934585, 135650329, 152258813, 160647664, 170474665, 185977010, 218916867, 237283038, 241069840, 251963102, 252436213, 252479045
Target and Pathway
Target(s) GPR40 Target Info Antagonist [528205]
KEGG Pathway Insulin secretion
Reactome G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways GPCRs, Class A Rhodopsin-like
Incretin Synthesis, Secretion, and Inactivation
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 538640(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1057).
Ref 528205Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28. Epub 2006 May 15.

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