Drug Information

Drug General Information
Drug ID
D03VZH
Former ID
DAP000163
Drug Name
Ethchlorvynol
Synonyms
Alvinol; Arvynol; Etchlorvinolo; Etclorvinol; Ethchlorovynol; Ethchlorvinol; Ethchlorvinyl; Ethchlorvynolum;Ethclorvynol; Ethochlorvynol; Ethychlorvynol; Normonson; Normosan; Normoson; Nostel; Nromoson; Placidil; Placidyl; Roeridorm; Serenesil; Serenil; Serensil; Serensiloline; A 71; Aethyl-chlorvynol; Beta-Chlorovinyl ethyl ethynyl carbinol; Beta-Chlorvinyl ethyl ethynyl carbinol; Etclorvinol [INN-Spanish]; Ethchlorvynolum [INN-Latin]; Ethyl beta-chlorovinyl ethynyl carbinol; Placidyl (TN); Ethchlorvynol [USAN:INN:BAN]; Ethchlorvynol (JAN/USP/INN); (E)-1-chloro-3-ethylpent-1-en-4-yn-3-ol; 1-Chloro-3-ethyl-1-penten-4-yn-3-ol; 1-Chloro-3-ethylpent-1-4-yn-3-ol; 1-chloro-3-ethylpent-1-en-4-yn-3-ol; 3-(beta-Chlorovinyl)-1-pentyn-3-ol; 5-Chloro-3-ethylpent-1-yn-4-en-3-ol
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [538355], [542191]
Therapeutic Class
Hypnotics and Sedatives
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C7H9ClO
InChI
InChI=1S/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3/b6-5+
InChIKey
ZEHYJZXQEQOSON-AATRIKPKSA-N
CAS Number
CAS 113-18-8
PubChem Compound ID
5281077
PubChem Substance ID
10035, 7847769, 7979197, 8616506, 10504382, 15363676, 39289998, 46505006, 50003221, 52002170, 57358002, 99437354, 103181692, 103825403, 113854516, 117454917, 125330356, 126676858, 134222995, 134337483, 134973868, 137008512, 137254894, 152043177, 160963537, 162199557, 164841061, 178103755, 179225721, 179316266, 223655265, 226486209, 226486211, 249987023
SuperDrug ATC ID
N05CM08
SuperDrug CAS ID
cas=000113188
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit beta-2 Target Info Antagonist [536555]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
Serotonergic synapse
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 538355FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 084463.
Ref 542191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7180).
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.

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