Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03WPI
|
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| Former ID |
DIB001826
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| Drug Name |
NC-190
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| Synonyms |
NCU-190Na
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Discontinued in Phase 2 | [1] | ||
| Company |
Taisho Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H21N4NaO5
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| Canonical SMILES |
c12c(c(c(c3c1cccc3)O)C(=O)NCCN(C)C)nc1c(n2)cc(c(c1)C(=O<br />)[O-])OC.[Na+]
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Modulator | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000904) | ||||
| REF 2 | The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells. Res Commun Mol Pathol Pharmacol. 2002;111(1-4):77-87. | ||||
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