Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03XDX
|
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| Former ID |
DCL000244
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| Drug Name |
Tarazepide
|
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| Synonyms |
Tarazepide (INN)
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| Drug Type |
Small molecular drug
|
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| Indication | Gastrointestinal disease [ICD10:K00-K93] | Discontinued in Phase 2 | [1] | ||
| Company |
Solvay Pharma
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| Structure |
|
Download2D MOL |
|||
| Formula |
C28H24N4O2
|
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| Canonical SMILES |
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C3=CC4=C5N3CCCC5=CC=C4)C<br />6=CC=CC=C6
|
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| InChI |
1S/C28H24N4O2/c1-31-22-15-6-5-14-21(22)24(18-9-3-2-4-10-18)29-26(28(31)34)30-27(33)23-17-20-12-7-11-19-13-8-16-32(23)25(19)20/h2-7,9-12,14-15,17,26H,8,13,16H2,1H3,(H,30,33)/t26-/m1/s1
|
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| InChIKey |
CZPILLBHPRAPCB-AREMUKBSSA-N
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| CAS Number |
CAS 141374-81-4
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Cholecystokinin receptor type A | Target Info | Antagonist | [2], [3], [4] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. BMC Neurosci. 2012 Jun 8;13:63. | ||||
| REF 2 | The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats. J Physiol Pharmacol. 2006 Dec;57(4):691-700. | ||||
| REF 3 | Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:65-80. | ||||
| REF 4 | Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept. 1998 Nov 30;78(1-3):113-23. | ||||
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