Drug Information

Drug General Information
Drug ID
D03XIS
Former ID
DNC001190
Drug Name
R-568
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [542190], [546233]
Structure
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2D MOL

3D MOL
Formula
C18H22ClNO
InChI
InChI=1S/C18H22ClNO/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3/t14-/m1/s1
InChIKey
ZVQUCWXZCKWZBP-CQSZACIVSA-N
CAS Number
CAS 177172-49-5
PubChem Compound ID
158797
PubChem Substance ID
10253431, 14776285, 14923081, 46234175, 49880981, 53395017, 103251115, 104141199, 113440839, 129961715, 135220554, 135650741, 137240428, 139244553, 172919632, 174006311, 175445277, 179150078, 198948738, 226651059, 241037421, 242588983
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Agonist [538155]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542190(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 718).
Ref 546233Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007039)
Ref 538155Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. Clin Pharmacol Ther. 1999 Jan;65(1):40-9.

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