Drug General Information
Drug ID	D03YBR
Former ID	DNC005870
Drug Name	6-Phenylmethanesulfonyl-2H-pyridazin-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527771]
Structure		Download 2D MOL 3D MOL
Formula	C11H10N2O3S
Canonical SMILES	C1=CC=C(C=C1)CS(=O)(=O)C2=NNC(=O)C=C2
InChI	1S/C11H10N2O3S/c14-10-6-7-11(13-12-10)17(15,16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,12,14)
InChIKey	QUZYPEPCSQAPEU-UHFFFAOYSA-N
PubChem Compound ID	23647383
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[527771]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

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