Drug Information

Drug General Information
Drug ID
D03YDP
Former ID
DNC008898
Drug Name
C[Glu22-Orn26][Gly8]GLP-1(7-37)-NH2
Indication Discovery agent Investigative [529424]
Structure
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2D MOL

3D MOL
Formula
C152H227N41O47
Canonical SMILES
CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC<br />(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=<br />N)N)C(=O)NCC(=O)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O<br />)NC(=O)C4CCCNC(=O)CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)C<br />)C)CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC5<br />=CC=C(C=C5)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)<br />C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC6=CC=CC=C6<br />)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(C<br />C7=CNC=N7)N
InChI
1S/C152H227N41O47/c1-16-77(10)122(149(238)170-80(13)127(216)179-105(60-86-63-162-91-34-24-23-33-89(86)91)139(228)181-101(56-74(4)5)140(229)190-120(75(6)7)147(236)178-93(35-25-26-52-153)130(219)165-67-114(204)171-92(36-28-54-161-152(157)158)129(218)163-65-111(156)201)192-141(230)103(57-83-29-19-17-20-30-83)182-136(225)99(46-51-118(210)211)176-133(222)94-37-27-53-160-112(202)48-43-97(134(223)174-96(42-47-110(155)200)132(221)169-78(11)125(214)168-79(12)126(215)173-94)175-135(224)98(45-50-117(208)209)177-137(226)100(55-73(2)3)180-138(227)102(59-85-38-40-88(199)41-39-85)183-144(233)107(69-194)186-146(235)109(71-196)187-148(237)121(76(8)9)191-143(232)106(62-119(212)213)184-145(234)108(70-195)188-151(240)124(82(15)198)193-142(231)104(58-84-31-21-18-22-32-84)185-150(239)123(81(14)197)189-115(205)68-166-131(220)95(44-49-116(206)207)172-113(203)66-164-128(217)90(154)61-87-64-159-72-167-87/h17-24,29-34,38-41,63-64,72-82,90,92-109,120-124,162,194-199H,16,25-28,35-37,42-62,65-71,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,218)(H,164,217)(H,165,219)(H,166,220)(H,168,214)(H,169,221)(H,170,238)(H,171,204)(H,172,203)(H,173,215)(H,174,223)(H,175,224)(H,176,222)(H,177,226)(H,178,236)(H,179,216)(H,180,227)(H,181,228)(H,182,225)(H,183,233)(H,184,234)(H,185,239)(H,186,235)(H,187,237)(H,188,240)(H,189,205)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,161)/t77-,78-,79-,80-,81-,82-,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-,124-/m0/s1
InChIKey
KMMGHNYLBGRIJN-NINLSKNRSA-N
PubChem Compound ID
44577343
Target and Pathway
Target(s) Glucagon-like peptide 1 receptor Target Info Inhibitor [529424]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 529424J Med Chem. 2008 May 8;51(9):2758-65. Epub 2008 Apr 15.Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.
Ref 529424J Med Chem. 2008 May 8;51(9):2758-65. Epub 2008 Apr 15.Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

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