Drug Information

Drug General Information
Drug ID
D03YEG
Former ID
DIB014364
Drug Name
REGN-910
Synonyms
SAR-307746; SAR-3077646; Anti-angiopoietin-2 antibody (cancer), Regeneron/sanofi-aventis
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [523314]
Company
Regeneron Pharmaceuticals Inc
Target and Pathway
Target(s) Angiopoietin-2 Target Info [532117]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
Reactome Tie2 Signaling
WikiPathways Cell surface interactions at the vascular wall
References
Ref 523314ClinicalTrials.gov (NCT01271972) Study of Nesvacumab (REGN910/ SAR307746). U.S. National Institutes of Health.
Ref 532117Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res. 2013 Jan 1;73(1):108-18.

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