Drug Information

Drug General Information
Drug ID
D03YGR
Former ID
DAP000256
Drug Name
Cinacalcet
Synonyms
Cinacalcet [INN]; AMG 073; AMG073; Cinacalcet (USAN); Mimpara (TN); Sensipar (TN); N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
Drug Type
Small molecular drug
Indication Hyperparathyroidism [ICD9: 252.02, 588.81; ICD10:E21.1] Approved [538572], [540268]
Cardiovascular disease; Kidney disease [ICD9: 390-459, 580-589; ICD10:I00-I99, N00-N29] Phase 3 [538572], [540268]
Therapeutic Class
Calcimimetics
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C22H22F3N
InChI
InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
InChIKey
VDHAWDNDOKGFTD-MRXNPFEDSA-N
CAS Number
CAS 226256-56-0
PubChem Compound ID
156419
PubChem Substance ID
10252916, 14828105, 17397638, 26746623, 46232233, 46506315, 49658855, 49831866, 50070910, 50125742, 50963794, 57348294, 87325440, 99460880, 113435046, 123094726, 124772063, 124893630, 126616831, 126659507, 126666798, 134337570, 134339698, 135182927, 135723717, 137004918, 139773348, 152049240, 152258881, 160647730, 160964348, 162202444, 163365899, 164161045, 164765368, 164826120, 165237999, 174528429, 175268532, 176484923, 178100343, 179117002, 184816362, 223536062, 223664882, 224084531, 226452146, 241053841, 242598530, 243678877
ChEBI ID
ChEBI:48390
SuperDrug ATC ID
H05BX01
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Agonist [550250]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538572FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021688.
Ref 540268(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3308).
Ref 550250Clinical pipeline report, company report or official report of Amgen (2009).

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