Drug General Information
Drug ID
D03YIO
Former ID
DNC002455
Drug Name
Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL
Formula
C11H18N5O12P3
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(CP(=O<br />)(O)O)O)O)O
InChI
1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
InChIKey
UFZTZBNSLXELAL-IOSLPCCCSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Insulin receptor Target Info Inhibitor [551393]
Pyridoxal kinase Target Info Inhibitor [551393]
BioCyc Pathway Pyridoxal 5'-phosphate salvage
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorptionhsa00750:Vitamin B6 metabolism
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathwayP02770:Pyridoxal phosphate salvage pathway
Vitamin B6 metabolism
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin SignalingPW000053:Vitamin B6 Metabolism
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK SignalingWP1857:Metabolism of water-soluble vitamins and cofactors
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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