Drug Information

Drug General Information
Drug ID
D03ZBT
Former ID
DNAP001679
Drug Name
Crizotinib
Synonyms
Xalkori (TN); novel ALK inhibitors
Drug Type
Small molecular drug
Indication ALK-positive advanced or metastatic NSCLC [ICD9: 162; ICD10:C33, C34] Approved [468091], [531783]
Company
Pfizer New York, NY
Structure
Download
2D MOL

3D MOL
Formula
C21H22Cl2FN5O
InChI
InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChIKey
KTEIFNKAUNYNJU-GFCCVEGCSA-N
CAS Number
CAS 877399-52-5
PubChem Compound ID
11626560
PubChem Substance ID
16729581, 23733583, 74374126, 75543391, 93581001, 99309272, 99437209, 99445171, 103728028, 104161043, 119526687, 121278669, 124490471, 124756975, 125163780, 125299329, 126659900, 131407280, 135264650, 135668295, 135727397, 136345871, 136367829, 136920405, 137232008, 137275901, 141226597, 143499147, 152040652, 152134626, 152237527, 152258843, 152344161, 160644611, 160647693, 160815247, 160969694, 162010188, 162010189, 162011538, 162196520, 162927269, 163565316, 163590241, 164041842, 164193931, 165245564, 170497919, 174531154, 175265614
SuperDrug ATC ID
L01XE16
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Hepatocyte growth factor receptor Target Info Modulator [551871]
ROS1 Target Info Modulator [551871]
ALK tyrosine kinase receptor Target Info Modulator [551871]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancerhsa05223:Non-small cell lung cancer
Pathway Interaction Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma protein
Reactome Sema4D mediated inhibition of cell attachment and migration
WikiPathways TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactionsWP2431:Spinal Cord InjuryWP2848:Differentiation Pathway
References
Ref 468091(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4903).
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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