Drug Information

Drug General Information
Drug ID
D03ZKE
Former ID
DCL000759
Drug Name
CS-003
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 2 [536223]
Company
Sankyo
Structure
Download
2D MOL

3D MOL
Formula
C35H39Cl2NO6S
Canonical SMILES
COC1=CC(=CC(=C1OC)OC)C(=O)N2CCOCC2(CCC3CCC4(CC3)C5=CC=C<br />C=C5CS4=O)C6=CC(=C(C=C6)Cl)Cl
InChI
1S/C35H39Cl2NO6S/c1-41-30-18-25(19-31(42-2)32(30)43-3)33(39)38-16-17-44-22-34(38,26-8-9-28(36)29(37)20-26)13-10-23-11-14-35(15-12-23)27-7-5-4-6-24(27)21-45(35)40/h4-9,18-20,23H,10-17,21-22H2,1-3H3/t23?,34-,35?,45?/m1/s1
InChIKey
ZNZYXGOBVCQIIG-WANOBJFPSA-N
PubChem Compound ID
56603711
PubChem Substance ID
134339247
Target and Pathway
Target(s) NK-2 receptor Target Info Antagonist [536223]
Substance-P receptor Target Info Antagonist [536223]
Nigral tachykinin NK(3) receptor Target Info Antagonist [536223]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measleshsa04020:Calcium signaling pathway
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.

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