Drug Information

Drug General Information
Drug ID
D04AEG
Former ID
DNC007798
Drug Name
3-(2-phenylthiazol-4-yl)quinolin-2(1H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528992]
Structure
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2D MOL

3D MOL
Formula
C18H12N2OS
Canonical SMILES
C1=CC=C(C=C1)C2=NC(=CS2)C3=CC4=CC=CC=C4NC3=O
InChI
1S/C18H12N2OS/c21-17-14(10-13-8-4-5-9-15(13)19-17)16-11-22-18(20-16)12-6-2-1-3-7-12/h1-11H,(H,19,21)
InChIKey
OANBFUCSFFQVAU-UHFFFAOYSA-N
PubChem Compound ID
22638512
Target and Pathway
Target(s) Cell division protein kinase 5 Target Info Inhibitor [528992]
KEGG Pathway Axon guidance
Alzheimer's disease
Cocaine addiction
NetPath Pathway EGFR1 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Axon guidance mediated by semaphorins
Pathway Interaction Database Reelin signaling pathway
Glucocorticoid receptor regulatory network
Lissencephaly gene (LIS1) in neuronal migration and development
EPHA forward signaling
Trk receptor signaling mediated by the MAPK pathway
Reactome DARPP-32 events
CRMPs in Sema3A signaling
Factors involved in megakaryocyte development and platelet production
WikiPathways DNA Damage Response
BDNF signaling pathway
Alzheimers Disease
Opioid Signalling
Semaphorin interactions
Factors involved in megakaryocyte development and platelet production
Nicotine Activity on Dopaminergic Neurons
miRNA Regulation of DNA Damage Response
References
Ref 528992Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. Epub 2007 Aug 6.Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Ref 528992Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. Epub 2007 Aug 6.Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.

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