Drug General Information
Drug ID	D04AXR
Former ID	DNC007200
Drug Name	4-chloro-1H-indole-2,3-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528749]
Structure		Download 2D MOL 3D MOL
Formula	C8H4ClNO2
Canonical SMILES	C1=CC2=C(C(=C1)Cl)C(=O)C(=O)N2
InChI	1S/C8H4ClNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12)
InChIKey	HSYFISNDMZKGRS-UHFFFAOYSA-N
PubChem Compound ID	96047
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528749]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749	J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

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