Drug General Information
Drug ID	D04BGT
Former ID	DNC010608
Drug Name	4-propyl-6-m-tolylpyrimidine-2-carbonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531005]
Structure		Download 2D MOL 3D MOL
Formula	C15H15N3
Canonical SMILES	CCCC1=NC(=NC(=C1)C2=CC(=CC=C2)C)C#N
InChI	1S/C15H15N3/c1-3-5-13-9-14(18-15(10-16)17-13)12-7-4-6-11(2)8-12/h4,6-9H,3,5H2,1-2H3
InChIKey	LWTLVKKUNGVFHE-UHFFFAOYSA-N
PubChem Compound ID	46881451
Target and Pathway
Target(s)	Cathepsin K	Target Info	Inhibitor	[531005]
	Cathepsin S	Target Info	Inhibitor	[531005]
KEGG Pathway	Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritishsa04142:Lysosome
	Phagosome
	Antigen processing and presentation
	Tuberculosis
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling PathwayNetPath_22:Leptin Signaling Pathway
	IL2 Signaling Pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Trafficking and processing of endosomal TLR
	MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	RANKL/RANK Signaling Pathway
	Osteoclast SignalingWP2796:Class I MHC mediated antigen processing & presentation
	Trafficking and processing of endosomal TLR
References
Ref 531005	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. Epub 2010 Jun 15.2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Ref 531005	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. Epub 2010 Jun 15.2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

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