TTD | Drug: D04BLO

Drug General Information
Drug ID	D04BLO
Former ID	DIB019738
Drug Name	difluoroagomelatine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542728]
Structure		Download 2D MOL
Formula	C15H15F2NO2
InChI	InChI=1S/C15H15F2NO2/c1-20-12-6-5-10-3-2-4-11(13(10)9-12)7-8-18-15(19)14(16)17/h2-6,9,14H,7-8H2,1H3,(H,18,19)
InChIKey	UTLRQLQDJLNKNY-UHFFFAOYSA-N
PubChem Compound ID	57381112
PubChem Substance ID	136887056, 136944457, 223366109
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Agonist	[531787]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542728	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7776).
Ref 531787	Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). Eur J Med Chem. 2012 Mar;49:310-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information