Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04CON
|
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| Former ID |
DIB015958
|
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| Drug Name |
SL-89.0591
|
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| Indication | Prostate disease [ICD10:N42.9] | Discontinued in Phase 2 | [1] | ||
| Company |
Synthelabo
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
N1(c2cc(ccc2OC)Cl)CCN(CC1)CCCNc1nc(C(=O)N)ccn1
|
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| CAS Number |
CAS 194674-19-6
|
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| Target and Pathway | |||||
| Target(s) | Alpha-1D adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003628) | ||||
| REF 2 | Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373(1):51-62. | ||||
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