Drug General Information |
Drug ID |
D04CVC
|
Former ID |
DNC004888
|
Drug Name |
4-Amino-3-fluoro-benzenesulfonamide
|
Synonyms |
4-amino-3-fluorobenzenesulfonamide
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Canonical SMILES |
C1=CC(=C(C=C1S(=O)(=O)N)F)N
|
InChI |
1S/C6H7FN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11)
|
InChIKey |
HVFBADWBKHAPKV-UHFFFAOYSA-N
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Target and Pathway |
Target(s) |
Carbonic anhydrase I |
Target Info |
Inhibitor |
[2]
|
Carbonic anhydrase |
Target Info |
Inhibitor |
[1]
|
Carbonic anhydrase IV |
Target Info |
Inhibitor |
[3]
|
Carbonic anhydrase XII |
Target Info |
Inhibitor |
[4]
|
Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[5]
|
Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
Carbonic anhydrase VI |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Nitrogen metabolismhsa00910:Nitrogen metabolism
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Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
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EGFR1 Signaling Pathway
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Pathway Interaction Database
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C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Gastric Acid Production
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
|
References |
REF 1 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. |
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REF 2 | Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. Epub 2010 Jun 22.Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. |
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REF 3 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. |
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REF 4 | Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. |
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REF 5 | Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. |