Drug Information

Drug General Information
Drug ID
D04CXY
Former ID
DIB010486
Drug Name
Hedgehog pathway antagonists
Synonyms
Hedgehog pathway antagonists (cancer); Hedgehog pathway antagonists (cancer), IRBM; Hh pathway antagonists (cancer), IRBM
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552171]
Company
Istituto di Ricerche di Biologia Molecolare Pietro Angeletti
Structure
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2D MOL

3D MOL
Canonical SMILES
c1cc(cc2c1n(nc2)c1ccccc1OC)CNC(=O)C(CCC)CCC
Target and Pathway
Target(s) smoothened receptor Target Info Antagonist [543616]
KEGG Pathway Hedgehog signaling pathway
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
PANTHER Pathway Hedgehog signaling pathway
Pathway Interaction Database Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
Reactome Class B/2 (Secretin family receptors)
Hedgehog 'off' state
Activation of SMO
WikiPathways Hedgehog Signaling Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
GPCR ligand binding
GPCRs, Other
References
Ref 552171US patent application no. 2009048259 , PHTHALAZINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE.
Ref 543616(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239).

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