Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04CXY
|
||||
| Former ID |
DIB010486
|
||||
| Drug Name |
Hedgehog pathway antagonists
|
||||
| Synonyms |
Hedgehog pathway antagonists (cancer); Hedgehog pathway antagonists (cancer), IRBM; Hh pathway antagonists (cancer), IRBM
|
||||
| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
| Company |
Istituto di Ricerche di Biologia Molecolare Pietro Angeletti
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c1cc(cc2c1n(nc2)c1ccccc1OC)CNC(=O)C(CCC)CCC
|
||||
| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Hedgehog signaling pathway | ||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Basal cell carcinoma | |||||
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| Reactome | Class B/2 (Secretin family receptors) | ||||
| Hedgehog 'off' state | |||||
| Activation of SMO | |||||
| WikiPathways | Hedgehog Signaling Pathway | ||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| GPCR ligand binding | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | US patent application no. 2009048259 , PHTHALAZINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.