Drug Information

Drug General Information
Drug ID
D04DKM
Former ID
DIB018078
Drug Name
(1S,3R)-ACPD
Synonyms
(1S,3R)-1-ACPD; trans-ACPD; (1S,3S)-ACPD; 1S,3R-ACPD
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538843]
Structure
Download
2D MOL
Formula
C7H11NO4
InChI
InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
InChIKey
YFYNOWXBIBKGHB-FBCQKBJTSA-N
PubChem Compound ID
104766
PubChem Substance ID
7978513, 10233597, 14772609, 17404660, 24890591, 44434377, 47736593, 47959870, 48185094, 49959005, 50104329, 50104330, 53777203, 53837809, 57337829, 79091859, 87691008, 90341793, 91702841, 92303591, 103068735, 103078459, 103204760, 103942696, 104372878, 117541915, 121360860, 124749444, 129790327, 135060901, 135365907, 135649666, 137133099, 137783325, 140862489, 144220604, 162226686, 163302678, 163564051, 164823306, 164823307, 164848256, 184526316, 212343803, 226540646, 241181603, 252645287
Target and Pathway
Target(s) mGlu6 receptor Target Info Agonist [543751]
Metabotropic glutamate receptor 7 Target Info Agonist [525945]
Metabotropicglutamate receptor 1 Target Info Agonist [525911]
Metabotropic glutamate receptor 8 Target Info Agonist [534561]
Metabotropic glutamate receptor 5 Target Info Agonist [525911]
Metabotropic glutamate receptor3 Target Info Agonist [525619]
Metabotropic glutamate receptor 2 Target Info Agonist [525619]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04020:Calcium signaling pathway
FoxO signaling pathway
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Huntington's diseasehsa04080:Neuroactive ligand-receptor interaction
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
References
Ref 538843(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1365).
Ref 525619[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29.
Ref 525911Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.
Ref 525945Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
Ref 534561Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97.
Ref 543751(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294).

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