Drug General Information
Drug ID	D04FDN
Former ID	DNCL002263
Drug Name	Palifosfamide
Synonyms	ZIO-201
Drug Type	Small molecular drug
Indication	Soft tissue sarcoma [ICD9: 171; ICD10:C00-D49]		Phase 2	[524236]
Company	ZIOPHARM Oncology
Structure		Download 2D MOL 3D MOL
Formula	C4H11Cl2N2O2P
Canonical SMILES	C(CCl)NP(=O)(NCCCl)O
InChI	1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
InChIKey	BKCJZNIZRWYHBN-UHFFFAOYSA-N
PubChem Compound ID	100427
PubChem Substance ID	147379, 5200075, 10231313, 11406886, 15018727, 44430549, 50008947, 51090888, 77374038, 96026044, 103233784, 104361564, 125715630, 127527276, 135059060, 135223995, 135653364, 137244673, 140837753, 162785738, 163620814, 163686142, 186022462, 198980540, 223445554, 227992071, 250063902, 251963175
Target and Pathway
Target(s)	DNMT1	Target Info	Inhibitor	[531674]
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
	MicroRNAs in cancer
Pathway Interaction Database	Regulation of retinoblastoma protein
PathWhiz Pathway	Methionine Metabolism
Reactome	PRC2 methylates histones and DNA
	NoRC negatively regulates rRNA expression
	DNA methylation
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Trans-sulfuration pathway
References
Ref 524236	ClinicalTrials.gov (NCT01808534) Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors. U.S. National Institutes of Health.
Ref 531674	Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23(2):173-84.

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