Drug Information

Drug General Information
Drug ID
D04HDO
Former ID
DNC004909
Drug Name
3-Phenethyl-2-phenyl-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527460]
Structure
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2D MOL

3D MOL
Formula
C22H18N2O
Canonical SMILES
C1=CC=C(C=C1)CCN2C(=NC3=CC=CC=C3C2=O)C4=CC=CC=C4
InChI
1S/C22H18N2O/c25-22-19-13-7-8-14-20(19)23-21(18-11-5-2-6-12-18)24(22)16-15-17-9-3-1-4-10-17/h1-14H,15-16H2
InChIKey
KANHEDFPOIQKTH-UHFFFAOYSA-N
PubChem Compound ID
947434
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Inhibitor [527460]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527460Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60.3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.
Ref 527460Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60.3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.

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