Drug Information

Drug General Information
Drug ID
D04HQT
Former ID
DIB020758
Drug Name
proglumide
Synonyms
Milid; Nulsa; W-5219
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543285]
Structure
Download
2D MOL
Formula
C18H26N2O4
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N
PubChem Compound ID
4922
PubChem Substance ID
5236624, 7848880, 8149717, 8153032, 10321573, 11335859, 11361098, 11364226, 11366788, 11369350, 11372506, 11373889, 11377512, 11462070, 11466268, 11467388, 11485188, 11485976, 11489222, 11491259, 11492240, 11495146, 14777663, 17405393, 26612175, 26680275, 26747589, 26747590, 29224000, 47515325, 47662292, 47810761, 47810762, 47810763, 47885426, 48110460, 48185002, 48416475, 49698766, 49834543, 49972990, 50106676, 50106677, 50226741, 53777938, 56463359, 57288819, 57322526, 85088918, 85231119
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [533453]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543285(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 893).
Ref 533453Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung. 1987 Nov;37(11):1265-8.

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