Drug Information

Drug General Information
Drug ID
D04HYP
Former ID
DNC000133
Drug Name
ABT-594
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [540604], [546684]
Structure
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2D MOL

3D MOL
Formula
C9H11ClN2O
InChI
InChI=1S/C9H11ClN2O/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7/h1-2,5,7,11H,3-4,6H2/t7-/m1/s1
InChIKey
MKTAGSRKQIGEBH-SSDOTTSWSA-N
CAS Number
CAS 198283-73-7
PubChem Compound ID
3075702
PubChem Substance ID
7978538, 9468438, 12015176, 14773070, 15120933, 36407539, 50031243, 57354234, 75481931, 96099964, 103307513, 103958163, 111672363, 128609911, 132562988, 134339652, 135222621, 137053249, 142603812, 162224017, 178100815, 198960273, 224745216, 226491819, 249799507, 251962933
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-2 chain Target Info Agonist [534971]
Neuronal acetylcholine receptor protein, alpha-4 chain Target Info Agonist [534971]
Nicotinic acetylcholine receptor Target Info Agonist [534971], [538100]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
Nicotine Activity on Dopaminergic Neurons
References
Ref 540604(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3989).
Ref 546684Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009632)
Ref 534971The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions. Neuroreport. 1999 Dec 16;10(18):3909-13.
Ref 538100ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94.

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