Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04IFU
|
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| Former ID |
DCL000393
|
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| Drug Name |
GSK835726
|
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| Drug Type |
Small molecular drug
|
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| Indication | Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] | Discontinued in Phase 2 | [548731] | ||
| Company |
GSK
|
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| Structure |
|
Download2D MOL |
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| Formula |
C42H47F3N4O8
|
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| Canonical SMILES |
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCCN)NC(=O)C(CC3CCCCC<br />3)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46.C(=O)(C(F)(F)F)O
|
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| InChI |
1S/C40H46N4O6.C2HF3O2/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33;3-2(4,5)1(6)7/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48);(H,6,7)/t34-,35-;/m0./s1
|
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| InChIKey |
NLKOPSMADZXEPE-WDAFUDAASA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [550963] | |
| Histamine H3 receptor | Target Info | Antagonist | [550963] | ||
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| References | |||||
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