Drug General Information
Drug ID
D04JFT
Former ID
DIB011323
Drug Name
KW-5139
Synonyms
KW-1539; [Leu13]-motilin
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [545295]
Company
Kyowa Hakko Kogyo Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C121H190N34O35
Canonical SMILES
N1(C(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N)C(C)C)[C@H](C(=O<br />)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O<br />)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]<br />(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N<br />[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O<br />)CCC(=O)N)CCCCN)CC(=O)N)CCCNC(=N)N)CCC(=O)O)CCCCN)CCC(=<br />O)O)CCC(=O)N)CC(C)C)CCCNC(=N)N)CCC(=O)N)CC(C)C)CCC(=O)O<br />)Cc2ccc(cc2)O)[C@H](O)C)Cc2ccccc2)[C@H](CC)C)CCC1
CAS Number
CAS 59530-69-7
PubChem Compound ID
Target and Pathway
Target(s) Motilin receptor Target Info Modulator [533848]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 545295Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002731)
Ref 533848Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94.

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