Drug Information

Drug General Information
Drug ID
D04JQR
Former ID
DIB009989
Drug Name
LY-367385
Synonyms
LY-367385; Metabotropic mGluR1 agonists, Lilly; L-367385 analogs, Lilly
Drug Type
Small molecular drug
Indication Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10:I21, I22, R52, R52.1-R52.2, R60.9, G89] Terminated [538856], [546917]
Company
Lilly Research Centre Ltd
Structure
Download
2D MOL

3D MOL
Formula
C10H11NO4
InChI
InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
InChIKey
SGIKDIUCJAUSRD-QMMMGPOBSA-N
CAS Number
CAS 198419-91-9
PubChem Compound ID
5311261
PubChem Substance ID
7979830, 11056388, 11113985, 15220186, 26752128, 39340963, 47583762, 47657136, 50143872, 56311605, 103305778, 103983724, 114155688, 135306019, 135650555, 135698409, 152063303, 162248933, 170485582, 226959373, 241180694, 241182259, 249615237
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Agonist [525454]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538856(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1379).
Ref 546917Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011092)
Ref 525454Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24.

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