TTD | Drug: D04JXA

Drug General Information
Drug ID	D04JXA
Former ID	DIB021206
Drug Name	W54011
Synonyms	W-54011; W 54011
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541130]
Structure		Download 2D MOL
Formula	C30H36N2O2
InChI	InChI=1S/C30H36N2O2/c1-21(2)23-11-16-26(17-12-23)32(20-22-9-14-25(15-10-22)31(3)4)30(33)28-8-6-7-24-13-18-27(34-5)19-29(24)28/h9-19,21,28H,6-8,20H2,1-5H3
InChIKey	DVYASSBBADJRAS-UHFFFAOYSA-N
PubChem Compound ID	5311122
PubChem Substance ID	15202772, 23941549, 39340840, 80864053, 114155319, 124957905, 141323709, 178100221, 223885709, 228015444, 242856098
Target and Pathway
Target(s)	C5aR	Target Info	Antagonist	[526441]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Staphylococcus aureus infection
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541130	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 581).
Ref 526441	Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem. 2002 Dec 20;277(51):49403-7. Epub 2002 Oct 15.

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Drug Information