Drug Information

Drug General Information
Drug ID
D04LEF
Former ID
DIB020104
Drug Name
JMV449
Synonyms
JMV 449; JMV-449
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538954]
Structure
Download
2D MOL
Formula
C38H66N8O7
InChI
InChI=1S/C38H66N8O7/c1-5-25(4)33(36(50)44-31(38(52)53)21-24(2)3)45-34(48)30(22-26-14-16-28(47)17-15-26)43-35(49)32-13-10-20-46(32)37(51)29(12-7-9-19-40)42-23-27(41)11-6-8-18-39/h14-17,24-25,27,29-33,42,47H,5-13,18-23,39-41H2,1-4H3,(H,43,49)(H,44,50)(H,45,48)(H,52,53)/t25-,27-,29-,30-,31-,32-,33-/m0/s1
InChIKey
TZCYVPLNMOJUIL-GULBXNHPSA-N
PubChem Compound ID
164415
PubChem Substance ID
7979671, 10255450, 15039360, 46238619, 57350404, 80085693, 103839300, 113453944, 117570136, 135119246, 135652224, 241375735, 249617466, 252156246
Target and Pathway
Target(s) Neurotensin receptor type 1 Target Info Agonist [526673]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538954(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1570).
Ref 526673Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Mol Pharmacol. 2003 Aug;64(2):421-9.

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