Drug Information

Drug General Information
Drug ID
D04MIG
Former ID
DIB020266
Drug Name
LY2087101
Synonyms
LY 2087101; LY-2087101
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540608]
Structure
Download
2D MOL
Formula
C15H11FN2OS2
InChI
InChI=1S/C15H11FN2OS2/c1-9-14(13(19)10-6-7-20-8-10)21-15(17-9)18-12-4-2-11(16)3-5-12/h2-8H,1H3,(H,17,18)
InChIKey
PEAMDZVDNYENPN-UHFFFAOYSA-N
PubChem Compound ID
11964458
PubChem Substance ID
17423533, 26683817, 36461525, 78660455, 178100818, 241376832, 249618088, 252157821
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-2 chain Target Info Modulator (allosteric modulator) [528221]
Neuronal acetylcholinereceptor subunit alpha-2 Target Info Modulator (allosteric modulator) [528221]
Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator (allosteric modulator) [528221]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic NeuronsWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
References
Ref 540608(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3992).
Ref 528221Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 2006 Sep;318(3):1108-17. Epub 2006 May 31.

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