Drug General Information
Drug ID	D04NPX
Former ID	DIB004873
Drug Name	ZD-1611
Synonyms	Endothelin antagonist, Zeneca
Indication	Hypotension [ICD9: 458, 796.3; ICD10:I95]		Discontinued in Phase 1	[546553]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(=O)(=O)(Nc1c(nc(cn1)C)OC)c1c(nccc1)c1ccc(CC(C(=O)O)(C<br />)C)cc1
CAS Number	CAS 186497-38-1
Target and Pathway
Target(s)	Endothelin-1 receptor	Target Info	Antagonist	[525566]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin secretion
	Pathways in cancer
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
Pathway Interaction Database	Endothelins
	EGFR-dependent Endothelin signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 546553	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008908)
Ref 525566	Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290(3):1085-91.

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