Drug Information

Drug General Information
Drug ID
D04NXR
Former ID
DIB005079
Drug Name
RO-16-8714
Synonyms
P-[(R)-3-[Bis-[(R)-beta-hydroxyphenethyl]amino]butyl]benzamide
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Discontinued in Phase 1 [544945]
Structure
Download
2D MOL

3D MOL
Formula
C27H32N2O3
Canonical SMILES
CC(CCC1=CC=C(C=C1)C(=O)N)N(CC(C2=CC=CC=C2)O)CC(C3=CC=CC<br />=C3)O
InChI
1S/C27H32N2O3/c1-20(12-13-21-14-16-24(17-15-21)27(28)32)29(18-25(30)22-8-4-2-5-9-22)19-26(31)23-10-6-3-7-11-23/h2-11,14-17,20,25-26,30-31H,12-13,18-19H2,1H3,(H2,28,32)
InChIKey
OPPQEWZOPDBGAS-UHFFFAOYSA-N
PubChem Compound ID
146200
PubChem Substance ID
10249156, 14930081, 46223468, 53473773, 104413429, 128843367, 135102494, 232132884, 241174966
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [533155]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544945Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001618)
Ref 533155The novel thermogenic beta-adrenergic agonist Ro 16-8714 increases the interscapular brown-fat beta-receptor-adenylate cyclase and the uncoupling-protein mRNA level in obese (fa/fa) Zucker rats. Biochem J. 1989 Aug 1;261(3):721-4.

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