Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04ODQ
|
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| Former ID |
DIB006853
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| Drug Name |
447C88
|
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| Synonyms |
BW-447C88
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 1 | [1] | ||
| Company |
GlaxoSmithKline Inc
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c1(c(cc(cc1CCc1ccc(CC(C)(C)C)cc1)F)F)NC(=O)NCCCCCCC
|
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| CAS Number |
CAS 130400-16-7
|
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002257) | ||||
| REF 2 | The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur JClin Pharmacol. 1995;49(3):243-9. | ||||
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