Drug Information

Drug General Information
Drug ID
D04PHG
Former ID
DIB018565
Drug Name
2-methyl-3-phenethyl-3H-pyrimidin-4-one
Synonyms
compound 2H [PMID: 15863312]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527540]
Structure
Download
2D MOL

3D MOL
Formula
C21H21FN2O2
InChI
InChI=1S/C21H21FN2O2/c1-3-16-14(2)23-20(17-9-5-7-11-19(17)25)24(21(16)26)13-12-15-8-4-6-10-18(15)22/h4-11,23H,3,12-13H2,1-2H3/b20-17+
InChIKey
FYHAHJQDCZYGNJ-LVZFUZTISA-N
PubChem Compound ID
9841421
PubChem Substance ID
14802973, 44939499, 75517012, 92309408, 103465974, 104051962, 135649705, 137355180
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [527540]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527540Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40.Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones.
Ref 527540Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40.Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones.

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