Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04QDB
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| Former ID |
DNC006919
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| Drug Name |
ABT-341
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528488] | ||
| Structure |
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Download2D MOL |
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| Formula |
C21H18F9N5O3
|
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| Canonical SMILES |
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C3=CCC(C(C3)N)C4=CC(=C(C(<br />=C4)F)F)F.C(=O)(C(F)(F)F)O
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| InChI |
1S/C19H17F6N5O.C2HF3O2/c20-12-5-10(6-13(21)16(12)22)11-2-1-9(7-14(11)26)17(31)29-3-4-30-15(8-29)27-28-18(30)19(23,24)25;3-2(4,5)1(6)7/h1,5-6,11,14H,2-4,7-8,26H2;(H,6,7)/t11-,14+;/m1./s1
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| InChIKey |
JKIHWNQARLENJW-GGMFNZDASA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Dipeptidyl peptidase IV | Target Info | Inhibitor | [528488] | |
| KEGG Pathway | Protein digestion and absorption | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| References | |||||
| Ref 528488 | J Med Chem. 2006 Nov 2;49(22):6439-42.Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. | ||||
| Ref 528488 | J Med Chem. 2006 Nov 2;49(22):6439-42.Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. | ||||
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